The Post-transcriptional Regulator rsmA/csrA Activates T3SS by Stabilizing the 5′ UTR of hrpG, the Master Regulator of hrp/hrc Genes, in Xanthomonas
Identifieur interne : 000888 ( Main/Exploration ); précédent : 000887; suivant : 000889The Post-transcriptional Regulator rsmA/csrA Activates T3SS by Stabilizing the 5′ UTR of hrpG, the Master Regulator of hrp/hrc Genes, in Xanthomonas
Auteurs : Maxuel O. Andrade [États-Unis] ; Chuck S. Farah [Brésil] ; Nian Wang [États-Unis]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2014.
Abstract
The RsmA/CsrA family of the post-transcriptional regulators of bacteria is involved in the regulation of many cellular processes, including pathogenesis. In this study, we demonstrated that
Url:
DOI: 10.1371/journal.ppat.1003945
PubMed: 24586158
PubMed Central: 3937308
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Post-transcriptional Regulator <italic>rsmA</italic>/<italic>csrA</italic> Activates T3SS by Stabilizing the 5′ UTR of <italic>hrpG</italic>, the Master Regulator of <italic>hrp/hrc</italic> Genes, in <italic>Xanthomonas</italic></title><author><name sortKey="Andrade, Maxuel O" sort="Andrade, Maxuel O" uniqKey="Andrade M" first="Maxuel O." last="Andrade">Maxuel O. Andrade</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Citrus Research and Education Center, Department of Microbiology and Cell Sciences, University of Florida, Lake Alfred, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Citrus Research and Education Center, Department of Microbiology and Cell Sciences, University of Florida, Lake Alfred, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Farah, Chuck S" sort="Farah, Chuck S" uniqKey="Farah C" first="Chuck S." last="Farah">Chuck S. Farah</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, São Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Wang, Nian" sort="Wang, Nian" uniqKey="Wang N" first="Nian" last="Wang">Nian Wang</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Citrus Research and Education Center, Department of Microbiology and Cell Sciences, University of Florida, Lake Alfred, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Citrus Research and Education Center, Department of Microbiology and Cell Sciences, University of Florida, Lake Alfred, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24586158</idno><idno type="pmc">3937308</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937308</idno><idno type="RBID">PMC:3937308</idno><idno type="doi">10.1371/journal.ppat.1003945</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001235</idno><idno type="wicri:Area/Pmc/Curation">001234</idno><idno type="wicri:Area/Pmc/Checkpoint">000678</idno><idno type="wicri:Area/Ncbi/Merge">001611</idno><idno type="wicri:Area/Ncbi/Curation">001611</idno><idno type="wicri:Area/Ncbi/Checkpoint">001611</idno><idno type="wicri:doubleKey">1553-7366:2014:Andrade M:the:post:transcriptional</idno><idno type="wicri:Area/Main/Merge">000888</idno><idno type="wicri:Area/Main/Curation">000888</idno><idno type="wicri:Area/Main/Exploration">000888</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Post-transcriptional Regulator <italic>rsmA</italic>/<italic>csrA</italic> Activates T3SS by Stabilizing the 5′ UTR of <italic>hrpG</italic>, the Master Regulator of <italic>hrp/hrc</italic> Genes, in <italic>Xanthomonas</italic></title><author><name sortKey="Andrade, Maxuel O" sort="Andrade, Maxuel O" uniqKey="Andrade M" first="Maxuel O." last="Andrade">Maxuel O. Andrade</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Citrus Research and Education Center, Department of Microbiology and Cell Sciences, University of Florida, Lake Alfred, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Citrus Research and Education Center, Department of Microbiology and Cell Sciences, University of Florida, Lake Alfred, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Farah, Chuck S" sort="Farah, Chuck S" uniqKey="Farah C" first="Chuck S." last="Farah">Chuck S. Farah</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, São Paulo, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Wang, Nian" sort="Wang, Nian" uniqKey="Wang N" first="Nian" last="Wang">Nian Wang</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Citrus Research and Education Center, Department of Microbiology and Cell Sciences, University of Florida, Lake Alfred, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Citrus Research and Education Center, Department of Microbiology and Cell Sciences, University of Florida, Lake Alfred, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The RsmA/CsrA family of the post-transcriptional regulators of bacteria is involved in the regulation of many cellular processes, including pathogenesis. In this study, we demonstrated that <italic>rsmA</italic> not only is required for the full virulence of the phytopathogenic bacterium <italic>Xanthomonas citri</italic> subsp. citri (XCC) but also contributes to triggering the hypersensitive response (HR) in non-host plants. Deletion of <italic>rsmA</italic> resulted in significantly reduced virulence in the host plant sweet orange and a delayed and weakened HR in the non-host plant <italic>Nicotiana benthamiana</italic>. Microarray, quantitative reverse-transcription PCR, western-blotting, and GUS assays indicated that RsmA regulates the expression of the type 3 secretion system (T3SS) at both transcriptional and post-transcriptional levels. The regulation of T3SS by RsmA is a universal phenomenon in T3SS-containing bacteria, but the specific mechanism seems to depend on the interaction between a particular bacterium and its hosts. For Xanthomonads, the mechanism by which RsmA activates T3SS remains unknown. Here, we show that RsmA activates the expression of T3SS-encoding <italic>hrp/hrc</italic> genes by directly binding to the 5′ untranslated region (UTR) of <italic>hrpG</italic>, the master regulator of the <italic>hrp/hrc</italic> genes in XCC. RsmA stabilizes <italic>hrpG</italic> mRNA, leading to increased accumulation of HrpG proteins and subsequently, the activation of <italic>hrp/hrc</italic> genes. The activation of the <italic>hrp/hrc</italic> genes by RsmA via HrpG was further supported by the observation that ectopic overexpression of <italic>hrpG</italic> in an <italic>rsmA</italic> mutant restored its ability to cause disease in host plants and trigger HR in non-host plants. RsmA also stabilizes the transcripts of another T3SS-associated <italic>hrpD</italic> operon by directly binding to the 5′ UTR region. Taken together, these data revealed that RsmA primarily activates T3SS by acting as a positive regulator of <italic>hrpG</italic> and that this regulation is critical to the pathogenicity of XCC.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Buttner, D" uniqKey="Buttner D">D Buttner</name></author><author><name sortKey="Bonas, U" uniqKey="Bonas U">U Bonas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kay, S" uniqKey="Kay S">S Kay</name></author><author><name sortKey="Bonas, U" uniqKey="Bonas U">U Bonas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laia, Ml" uniqKey="Laia M">ML Laia</name></author><author><name sortKey="Moreira, Lm" uniqKey="Moreira L">LM Moreira</name></author><author><name sortKey="Dezajacomo, J" uniqKey="Dezajacomo J">J Dezajacomo</name></author><author><name sortKey="Brigati, Jb" uniqKey="Brigati J">JB 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Benjamini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boulanger, A" uniqKey="Boulanger A">A Boulanger</name></author><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name></author><author><name sortKey="Hinton, Dm" uniqKey="Hinton D">DM Hinton</name></author><author><name sortKey="Stibitz, S" uniqKey="Stibitz S">S Stibitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barbieri, Cm" uniqKey="Barbieri C">CM Barbieri</name></author><author><name sortKey="Stock, Am" uniqKey="Stock A">AM Stock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mitsuhara, I" uniqKey="Mitsuhara I">I Mitsuhara</name></author><author><name sortKey="Ugaki, M" uniqKey="Ugaki M">M Ugaki</name></author><author><name sortKey="Hirochika, H" uniqKey="Hirochika H">H Hirochika</name></author><author><name sortKey="Ohshima, M" uniqKey="Ohshima M">M Ohshima</name></author><author><name sortKey="Murakami, T" uniqKey="Murakami T">T Murakami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Staskawicz, B" uniqKey="Staskawicz B">B Staskawicz</name></author><author><name sortKey="Dahlbeck, D" uniqKey="Dahlbeck D">D Dahlbeck</name></author><author><name sortKey="Keen, N" uniqKey="Keen N">N Keen</name></author><author><name sortKey="Napoli, C" uniqKey="Napoli C">C Napoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Kh" uniqKey="Choi K">KH Choi</name></author><author><name sortKey="Gaynor, Jb" uniqKey="Gaynor J">JB Gaynor</name></author><author><name sortKey="White, Kg" uniqKey="White K">KG White</name></author><author><name sortKey="Lopez, C" uniqKey="Lopez C">C Lopez</name></author><author><name sortKey="Bosio, Cm" uniqKey="Bosio C">CM Bosio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsuge, S" uniqKey="Tsuge S">S Tsuge</name></author><author><name sortKey="Furutani, A" uniqKey="Furutani A">A Furutani</name></author><author><name sortKey="Fukunaka, R" uniqKey="Fukunaka R">R Fukunaka</name></author><author><name sortKey="Oku, T" uniqKey="Oku T">T Oku</name></author><author><name sortKey="Tsuno, K" uniqKey="Tsuno K">K Tsuno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jensen, Ec" uniqKey="Jensen E">EC Jensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crooks, Ge" uniqKey="Crooks G">GE Crooks</name></author><author><name sortKey="Hon, G" uniqKey="Hon G">G Hon</name></author><author><name sortKey="Chandonia, Jm" uniqKey="Chandonia J">JM Chandonia</name></author><author><name sortKey="Brenner, Se" uniqKey="Brenner S">SE Brenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bramucci, E" uniqKey="Bramucci E">E Bramucci</name></author><author><name sortKey="Paiardini, A" uniqKey="Paiardini A">A Paiardini</name></author><author><name sortKey="Bossa, F" uniqKey="Bossa F">F Bossa</name></author><author><name sortKey="Pascarella, S" uniqKey="Pascarella S">S Pascarella</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Brésil</li><li>États-Unis</li></country><region><li>Floride</li><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Andrade, Maxuel O" sort="Andrade, Maxuel O" uniqKey="Andrade M" first="Maxuel O." last="Andrade">Maxuel O. Andrade</name></region><name sortKey="Wang, Nian" sort="Wang, Nian" uniqKey="Wang N" first="Nian" last="Wang">Nian Wang</name></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Farah, Chuck S" sort="Farah, Chuck S" uniqKey="Farah C" first="Chuck S." last="Farah">Chuck S. Farah</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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